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Fantastic piece on Oliver Chu's stem-cell gene therapy at Manchester. The idea of harvesting, correcting, and reinfusing a patient's own cells to deliver therapeutic enzymes directly to the brain marks a real turning point in how we address metabolic disorders. It sidesteps both the graft-versus-host complications of donor marrows and the logistical burdens of weekly enzyme infusions, giving families like the Chus something closer to durable independence. One thing to watch is how the corrected stem cells maintain enzyme production over years as Oliver grows, since residual immunogenicity and off-target edits can sometimessurface late. Still, when you pair this with the bone-marrow-on-a-chip work and the broader movement toward patient-specific constructs, it feels like we're entering an era where gene editing isn't just a lab curiosity but a real first-line intervention.

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