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The tissue-specific protein tuning in worms is lowkey fascinating because it addresses what was basically an all-or-nothing problem in molecular biology. Being able to dial protein levels up or down in just the intestine while leaving neurons alone (or vice versa) opens up experiments that were impossible before. I worked briefly with C. elegans models and the binary nature of knockouts was always this frustrating limitation where you'd lose data because the organism couldn't compensate. The aging research implications are huge since different organs definitly need different protein balances over time.

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